Merck & Co., Inc.
Tremor tracks 194 of its cancer trials. This is a large company with many drugs, so one trial matters less to it, and company-wide signals count for half.
Company-wide warning signs
These add points to every one of this company's trials.
- 5 insiders sold shares within a monthSince Aug 13, 2026+1.9
Trials
- MRKMerck Sharp & Dohme LLC12Calm
Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304)
Running, no new patientsPhase 3808 patientsMain results: Oct 27, 2025 - MRKMerck Sharp & Dohme LLC12Calm
Substudy 02D: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Melanoma Brain Metastasis (MK-3475-02D/KEYMAKER-U02)
FinishedPhase 1/256 patientsMain results: Oct 17, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)
Signing up patientsPhase 1/2170 patientsMain results: Nov 29, 2030 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
Running, no new patientsPhase 3686 patientsMain results: Jun 15, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
Signing up patientsPhase 3876 patientsMain results: Aug 22, 2034 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Signing up patientsPhase 3680 patientsMain results: May 16, 2033 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) and Pembrolizumab (MK-3475A) in Participants With Bladder Cancer (MK-2870-055)
Signing up patientsPhase 3400 patientsMain results: Nov 17, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
Running, no new patientsPhase 296 patientsMain results: Mar 12, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Signing up patientsPhase 31,023 patientsMain results: Oct 29, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
Running, no new patientsPhase 3747 patientsMain results: Feb 2, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
Running, no new patientsPhase 31,688 patientsMain results: Feb 4, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)
Signing up patientsPhase 2372 patientsMain results: Dec 31, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).
Signing up patientsPhase 3735 patientsMain results: Jun 1, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)
FinishedPhase 1/235 patientsMain results: Sep 30, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance Treatment in Non-HRD-Positive Advanced Ovarian Cancer (MK-5909-006, (ENGOT-ov102/GOG-3141/ REJOICE-Ovarian 04)
Signing up patientsPhase 3802 patientsMain results: Mar 19, 2032 - MRKMerck Sharp & Dohme LLC2Calm
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
Signing up patientsPhase 31,530 patientsMain results: Dec 16, 2030 - MRKMerck Sharp & Dohme LLC2Calm
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Signing up patientsPhase 31,310 patientsMain results: Nov 30, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)
Signing up patientsPhase 2480 patientsMain results: Sep 26, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)
FinishedPhase 31,060 patientsMain results: Jan 7, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-1045 With Zilovertamab Vedotin in Participants With Diffuse Large B-cell Lymphoma (MK-1045-010)
Not started yetPhase 2/3470 patientsMain results: Mar 13, 2037 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Bomedemstat in Participants With Polycythemia Vera (MK-3543-025).
Signing up patientsPhase 2/3380 patientsMain results: Jun 25, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
Signing up patientsPhase 260 patientsMain results: Nov 16, 2033 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Signing up patientsPhase 3477 patientsMain results: Mar 28, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
Running, no new patientsPhase 2340 patientsMain results: Feb 12, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)
Signing up patientsPhase 3614 patientsMain results: Jan 25, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61)
FinishedPhase 2160 patientsMain results: Jan 27, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
Signing up patientsPhase 31,000 patientsMain results: Jul 14, 2033 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)
Signing up patientsPhase 3590 patientsMain results: Jul 27, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Signing up patientsPhase 2594 patientsMain results: Dec 13, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
Signing up patientsPhase 2355 patientsMain results: Nov 18, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
Signing up patientsPhase 2/3290 patientsMain results: Sep 24, 2027 - MRKMerck Sharp & Dohme LLC2Calm
MK-2870-U01 Substudy 1: A Clinical Trial of Sacituzumab Tirumotecan to Treat Prostate Cancer (MK-2870-01A)
Not started yetPhase 1/2290 patientsMain results: Jun 29, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Gocatamig (MK-6070) With Durvalumab in Participants With Small Cell Lung Cancer (MK-6070-004)
Not started yetPhase 3564 patientsMain results: Dec 8, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)
Signing up patientsPhase 3310 patientsMain results: Dec 15, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)
Signing up patientsPhase 2150 patientsMain results: Apr 9, 2032 - MRKMerck Sharp & Dohme LLC2Calm
MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)
Signing up patientsPhase 3400 patientsMain results: Oct 26, 2039 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Ifinatamab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01D/LIGHTBEAM-U01)
Signing up patientsPhase 1/2134 patientsMain results: Aug 17, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)
Signing up patientsPhase 2/3340 patientsMain results: Oct 18, 2033 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Signing up patientsPhase 1/290 patientsMain results: Mar 31, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Running, no new patientsPhase 3550 patientsMain results: Aug 17, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Signing up patientsPhase 31,440 patientsMain results: Jun 26, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05)
Signing up patientsPhase 3646 patientsMain results: Aug 31, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003).
Signing up patientsPhase 1/2605 patientsMain results: Mar 27, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Belzutifan in Adolescent Participants With Solid Tumors (MK-9999-01E/LIGHTBEAM-U01)
Signing up patientsPhase 215 patientsMain results: Jan 2, 2034 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)
FinishedPhase 3703 patientsMain results: Jan 21, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
Running, no new patientsPhase 1/2220 patientsMain results: Jan 15, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Signing up patientsPhase 1/2220 patientsMain results: Oct 16, 2029 - MRKMerck Sharp & Dohme LLC2Calm
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
Signing up patientsPhase 1/2450 patientsMain results: Feb 13, 2032 - MRKMerck Sharp & Dohme LLC2Calm
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Signing up patientsPhase 33,500 patientsMain results: Aug 4, 2043 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Signing up patientsPhase 3851 patientsMain results: Jan 12, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)
Signing up patientsPhase 3758 patientsMain results: Nov 27, 2030 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
Signing up patientsPhase 1/245 patientsMain results: Jul 30, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)
Signing up patientsPhase 1/2280 patientsMain results: Jul 1, 2030 - MRKMerck Sharp & Dohme LLC2Calm
KEYMAKER-U01 Substudy 2: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Treatment-naïve Participants With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Positive Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-01B/KEYMAKER-U01B)
FinishedPhase 2100 patientsMain results: Oct 31, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
Signing up patientsPhase 1/2270 patientsMain results: Feb 8, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)
Running, no new patientsPhase 1/260 patientsMain results: Dec 22, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Signing up patientsPhase 1/2298 patientsMain results: Jan 4, 2032 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
Signing up patientsPhase 1/2140 patientsMain results: Oct 26, 2031 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Signing up patientsPhase 2490 patientsMain results: Jan 4, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (MK-3475) in Relapsed or Refractory Classical Hodgkin's Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL) (MK-3475-B68)
FinishedPhase 266 patientsMain results: Dec 14, 2023 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)
Signing up patientsPhase 3348 patientsMain results: Jan 24, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)
Signing up patientsPhase 2/3960 patientsMain results: Jul 23, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
Signing up patientsPhase 3675 patientsMain results: Dec 7, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)
Running, no new patientsPhase 31,397 patientsMain results: Jul 31, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs Placebo Plus Chemotherapy as Neoadjuvant Therapy and Pembrolizumab vs Placebo as Adjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC) (MK-3475-522/KEYNOTE-522)
FinishedPhase 31,174 patientsMain results: Oct 14, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of V503 in Chinese Females Who Have Previously Received a Bivalent Human Papillomavirus (HPV) Vaccine (V503-108)
Signing up patientsPhase 3930 patientsMain results: Dec 18, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
Running, no new patientsPhase 3473 patientsMain results: Oct 19, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
Signing up patientsPhase 31,046 patientsMain results: Jul 2, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)
Signing up patientsPhase 3450 patientsMain results: Apr 22, 2034 - MRKMerck Sharp & Dohme LLC2Calm
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
Signing up patientsPhase 1/2181 patientsMain results: Aug 2, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Signing up patientsPhase 31,314 patientsMain results: May 10, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
Running, no new patientsPhase 3755 patientsMain results: Apr 15, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)
Running, no new patientsPhase 36,033 patientsMain results: Jan 15, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
Signing up patientsPhase 290 patientsMain results: Mar 12, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-2750 in Participants With Advanced Solid Tumors (MK-2750-002)
Not started yetPhase 1/2300 patientsMain results: Apr 12, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Signing up patientsPhase 3780 patientsMain results: Feb 21, 2034 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)
Signing up patientsPhase 2200 patientsMain results: Sep 30, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
Signing up patientsPhase 3900 patientsMain results: Feb 25, 2033 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
Signing up patientsPhase 31,000 patientsMain results: May 18, 2030 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Signing up patientsPhase 31,200 patientsMain results: Sep 7, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Signing up patientsPhase 3770 patientsMain results: Apr 27, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Signing up patientsPhase 32,400 patientsMain results: Mar 23, 2033 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
Signing up patientsPhase 31,200 patientsMain results: Jul 11, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01)
Running, no new patientsPhase 260 patientsMain results: Feb 6, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Signing up patientsPhase 31,123 patientsMain results: May 24, 2032 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
Signing up patientsPhase 1/2360 patientsMain results: Oct 1, 2031 - MRKMerck Sharp & Dohme LLC2Calm
Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866)
FinishedPhase 3907 patientsMain results: Jan 26, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
Signing up patientsPhase 1/2230 patientsMain results: Jun 11, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)
Signing up patientsPhase 2144 patientsMain results: Mar 2, 2032 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
Signing up patientsPhase 1/2160 patientsMain results: Sep 12, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)
Signing up patientsPhase 1/2327 patientsMain results: Feb 15, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)
Signing up patientsPhase 2250 patientsMain results: Nov 4, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)
Signing up patientsPhase 1/250 patientsMain results: Dec 30, 2030 - MRKMerck Sharp & Dohme LLC2Calm
KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)
Signing up patientsPhase 1/255 patientsMain results: Jul 8, 2031 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)
Signing up patientsPhase 1/260 patientsMain results: Jun 12, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Running, no new patientsPhase 1/2180 patientsMain results: Dec 7, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
Signing up patientsPhase 1/2140 patientsMain results: Aug 17, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Intismeran Autogene (V940)/Placebo + Pembrolizumab and Chemotherapy in Metastatic Squamous Non-Small Cell Lung Cancer (V940-013)
Signing up patientsPhase 2180 patientsMain results: Jul 2, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)
Signing up patientsPhase 2308 patientsMain results: Sep 3, 2031 - MRKMerck Sharp & Dohme LLC2Calm
MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)
FinishedPhase 2611 patientsMain results: Aug 5, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab With Maintenance Olaparib or Maintenance Pemetrexed in First-line (1L) Metastatic Nonsquamous Non-Small-Cell Lung Cancer (NSCLC) (MK-7339-006, KEYLYNK-006)
FinishedPhase 31,003 patientsMain results: Feb 7, 2024 - MRKMerck Sharp & Dohme LLC2Calm
A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)
Signing up patientsPhase 1/248 patientsMain results: Feb 26, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
Signing up patientsPhase 2160 patientsMain results: Jul 22, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)
FinishedPhase 1/2263 patientsMain results: Jul 23, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)
FinishedPhase 1/2393 patientsMain results: Aug 10, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)
Running, no new patientsPhase 3672 patientsMain results: Oct 28, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
FinishedPhase 285 patientsMain results: Aug 3, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Intismeran Autogene (V940) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
Running, no new patientsPhase 3868 patientsMain results: Jun 25, 2030 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)
Running, no new patientsPhase 3990 patientsMain results: Nov 20, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
Signing up patientsPhase 1/2210 patientsMain results: May 9, 2028 - MRKMerck Sharp & Dohme LLC2Calm
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Signing up patientsPhase 2140 patientsMain results: Nov 15, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)
FinishedPhase 2203 patientsMain results: Sep 3, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 02A: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents in Participants With Programmed Cell-death 1 (PD-1) Refractory Melanoma (MK-3475-02A/KEYMAKER-U02)
FinishedPhase 1/2100 patientsMain results: Aug 25, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy, Immunogenicity and Safety of V503 in Chinese Women Aged 20-45 Years (V503-023)
Running, no new patientsPhase 36,000 patientsMain results: Mar 31, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)
Running, no new patientsPhase 2120 patientsMain results: May 5, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)
Running, no new patientsPhase 3710 patientsMain results: Jan 10, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006)
FinishedPhase 3610 patientsMain results: Jun 15, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 02C: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Stage III Melanoma Who Are Candidates for Neoadjuvant Therapy (MK-3475-02C/KEYMAKER-U02)
FinishedPhase 1/2146 patientsMain results: Sep 24, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)
Running, no new patientsPhase 3377 patientsMain results: Jul 12, 2024 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension
Running, no new patientsPhase 339 patientsMain results: Nov 6, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)
FinishedPhase 3738 patientsMain results: Mar 20, 2024 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)
Running, no new patientsPhase 2189 patientsMain results: May 17, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study
Running, no new patientsPhase 3251 patientsMain results: Feb 4, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43/GOG-3036)
FinishedPhase 31,367 patientsMain results: Aug 26, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)
Running, no new patientsPhase 2329 patientsMain results: Aug 12, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)
Running, no new patientsPhase 3556 patientsMain results: May 10, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)
FinishedPhase 2122 patientsMain results: Jun 23, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)
Signing up patientsPhase 3904 patientsMain results: Feb 27, 2032 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)
Running, no new patientsPhase 3714 patientsMain results: Jul 25, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
Running, no new patientsPhase 3797 patientsMain results: Jul 10, 2023 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Running, no new patientsPhase 3342 patientsMain results: Apr 24, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) to Treat Newly-diagnosed Metastatic Non-small Cell Lung Cancer (MK-3475A-F84)
Running, no new patientsPhase 367 patientsMain results: Mar 12, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Adjuvant Intismeran Autogene (V940) and Pembrolizumab in Renal Cell Carcinoma (V940-004).
Running, no new patientsPhase 2272 patientsMain results: Jan 8, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)
Signing up patientsPhase 1/220 patientsMain results: Mar 30, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
Running, no new patientsPhase 1/21,200 patientsMain results: Oct 22, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
Signing up patientsPhase 1/2370 patientsMain results: Feb 2, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008).
Running, no new patientsPhase 2302 patientsMain results: May 21, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303)
Running, no new patientsPhase 3595 patientsMain results: Jun 6, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy of Coformulated Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib (E7080/MK-7902) in Advanced Hepatocellular Carcinoma (MK-1308A-004)
FinishedPhase 2116 patientsMain results: Jul 29, 2025 - MRKMerck Sharp & Dohme LLC2Calm
KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
FinishedPhase 2128 patientsMain results: Apr 30, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)
FinishedPhase 2333 patientsMain results: Jun 8, 2026 - MRKArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)2Calm
A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)
Running, no new patientsPhase 1/2190 patientsMain results: Sep 17, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy, Immunogenicity, and Safety Study of V503 (9-valent Human Papillomavirus [9vHPV] Vaccine) in Japanese Males (V503-064)
FinishedPhase 31,059 patientsMain results: Dec 31, 2023 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)
FinishedPhase 2245 patientsMain results: Jun 13, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy of MK-1200 in Participants With Advanced Solid Tumors (MK-1200-002)
FinishedPhase 1/213 patientsMain results: Jun 17, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
Running, no new patientsPhase 1/2110 patientsMain results: Dec 10, 2029 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)
FinishedPhase 2140 patientsMain results: Apr 21, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Substudy 02B: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With First Line (1L) Advanced Melanoma (MK-3475-02B/KEYMAKER-U02)
FinishedPhase 1/2335 patientsMain results: May 18, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)
FinishedPhase 3441 patientsMain results: Aug 15, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66)
Running, no new patientsPhase 3100 patientsMain results: Sep 19, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab With Concurrent Chemoradiation Therapy Followed by Pembrolizumab With or Without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK-7339-012/KEYLYNK-012)
Running, no new patientsPhase 3870 patientsMain results: May 5, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022)
Running, no new patientsPhase 31,800 patientsMain results: Oct 28, 2026 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
Running, no new patientsPhase 3280 patientsMain results: May 27, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
FinishedPhase 2611 patientsMain results: Oct 28, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992)
Running, no new patientsPhase 3520 patientsMain results: Jan 31, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)
FinishedPhase 3895 patientsMain results: Oct 29, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)
FinishedPhase 3959 patientsMain results: Mar 20, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)
Running, no new patientsPhase 2160 patientsMain results: Aug 18, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) Over Intravenous Pembrolizumab (MK-3475) Formulation in Multiple Tumor Types (MK-3475A-F11)
Running, no new patientsPhase 2147 patientsMain results: Apr 9, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Immunobridging Study of 9- Valent Human Papillomavirus (9vHPV) Vaccine (V503) in Chinese Females 9 to 45 Years of Age (V503-024)
FinishedPhase 31,990 patientsMain results: Feb 28, 2025 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)
Signing up patientsPhase 3400 patientsMain results: Dec 4, 2034 - MRKMerck Sharp & Dohme LLC2Calm
Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)
FinishedPhase 2163 patientsMain results: Mar 12, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)
Running, no new patientsPhase 3300 patientsMain results: May 19, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)
FinishedPhase 31,007 patientsMain results: Feb 16, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).
Running, no new patientsPhase 3643 patientsMain results: Mar 5, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)-China Extension
FinishedPhase 3120 patientsMain results: Feb 16, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Versus Placebo After Complete Resection of High-Risk Stage III Melanoma (MK-3475-054/1325-MG/KEYNOTE-054)
Running, no new patientsPhase 31,019 patientsMain results: Jan 8, 2018 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab/Vibostolimab (MK-7684A) in Relapsed/Refractory Hematological Malignancies (MK-7684A-004, KEYVIBE-004)
FinishedPhase 2192 patientsMain results: Dec 10, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) vs. Brentuximab Vedotin in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (MK-3475-204/KEYNOTE-204)
FinishedPhase 3304 patientsMain results: Jan 14, 2026 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)
Running, no new patientsPhase 1/238 patientsMain results: Mar 31, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Pembrolizumab (+) Berahyaluronidase Alfa (MK-3475A) (Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180)) in Japanese Participants With Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma (R/M cSCC) or Locally Advanced (LA) Unresectable cSCC (MK-3475A-E39)
Running, no new patientsPhase 219 patientsMain results: Mar 31, 2028 - MRKMerck Sharp & Dohme LLC2Calm
A Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) Coformulated With Berahyaluronidase Alfa (MK-3475A) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)(MK-3475A-F65)
Running, no new patientsPhase 266 patientsMain results: Nov 8, 2028 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076)
FinishedPhase 3165 patientsMain results: Dec 12, 2023 - MRKMerck Sharp & Dohme LLC2Calm
Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017)
FinishedPhase 3563 patientsMain results: Sep 27, 2024 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
Running, no new patientsPhase 1/2230 patientsMain results: Apr 23, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)
Running, no new patientsPhase 3614 patientsMain results: Jan 12, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)
FinishedPhase 1/290 patientsMain results: Dec 5, 2025 - MRKMerck Sharp & Dohme LLC2Calm
Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)
FinishedPhase 2408 patientsMain results: May 31, 2024 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study
FinishedPhase 394 patientsMain results: Aug 15, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab With Chemotherapy and MK-4830 for Treating Participants With Ovarian Cancer (MK-4830-002)
FinishedPhase 2160 patientsMain results: Dec 20, 2023 - MRKMerck Sharp & Dohme LLC2Calm
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
Running, no new patientsPhase 31,089 patientsMain results: Oct 26, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
Running, no new patientsPhase 21,609 patientsMain results: May 4, 2027 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Efficacy and Safety of Pembrolizumab Plus Enfortumab Vedotin (EV) +/- Investigational Agents in First-Line Metastatic Urothelial Carcinoma (mUC) (MK-3475-04B/KEYMAKER-U04)
Running, no new patientsPhase 1/2390 patientsMain results: May 31, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
Running, no new patientsPhase 31,240 patientsMain results: Jan 24, 2031 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
Running, no new patientsPhase 3460 patientsMain results: Jun 4, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Immunogenicity and Safety of the 9-valent Human Papillomavirus (9vHPV) Vaccine in Japanese Boys and Girls (V503-066)
FinishedPhase 3314 patientsMain results: Apr 6, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Immunogenicity of Extended 2-dose Regimens of 9-valent Human Papillomavirus (9vHPV) Vaccine (V503-069)
Running, no new patientsPhase 3700 patientsMain results: Oct 23, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)
FinishedPhase 1/2415 patientsMain results: Apr 8, 2024 - MRKMerck Sharp & Dohme LLC2Calm
Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)
Running, no new patientsPhase 2730 patientsMain results: Mar 22, 2027 - MRKMerck Sharp & Dohme LLC2Calm
Efficacy, Immunogenicity, and Safety of V503 in Chinese Males (V503-052)
Running, no new patientsPhase 38,100 patientsMain results: May 25, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
Running, no new patientsPhase 3976 patientsMain results: Jun 21, 2021 - MRKMerck Sharp & Dohme LLC2Calm
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)
Running, no new patientsPhase 260 patientsMain results: Apr 26, 2029 - MRKMerck Sharp & Dohme LLC2Calm
Immunogenicity and Safety of V503 in Chinese Males 9 Through 19 Years Old (V503-053)
Running, no new patientsPhase 31,590 patientsMain results: Feb 19, 2029 - MRKMerck Sharp & Dohme LLC2Calm
V503 in Chinese Girls 9-14 Years Old Versus Chinese Women 20-26 Years Old (V503-071)
Running, no new patientsPhase 31,500 patientsMain results: Aug 3, 2029
Key executives leaving
From the last 12 months of the company's SEC reports.
Insider trades (last 6 months)
“Insiders” are executives, board members, and big shareholders. Many of their sales are pre-planned: scheduled months ahead under a legal plan (called 10b5-1), so they usually say little. Tremor only counts sales that weren't pre-planned.
17 sales (17 not pre-planned) · 0 purchases
- Guindo ChirfiEVP, Access, Policy & Comms · Aug 13, 2026Sold 10,000 sharesabout $1.4 million · not pre-planned
- Zachary JenniferEVP, General Counsel · Aug 12, 2026Sold 80,315 sharesabout $10.7 million · not pre-planned
- DeLuca Richard R.EVP&Pres, Merck Animal Heallth · Aug 12, 2026Sold 11,099 sharesabout $1.5 million · not pre-planned
- DeLuca Richard R.EVP&Pres, Merck Animal Heallth · Aug 12, 2026Sold 600 sharesabout $79 thousand · not pre-planned
- DeLuca Richard R.EVP&Pres, Merck Animal Heallth · Aug 11, 2026Sold 7,410 sharesabout $973 thousand · not pre-planned
- DeLuca Richard R.
Recent SEC filings
Public companies must report important news and their finances to the SEC, the US agency that oversees the stock market.