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Tremor shows what changed in public records. It never tells anyone to buy or sell. Many trial edits are harmless paperwork. Data from ClinicalTrials.gov, the SEC, and the Federal Register.

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MRKMerck Sharp & Dohme LLCRunning, no new patients

Pembrolizumab Plus Lenvatinib in Combination With Belzutifan in Solid Tumors (MK-6482-016)

Neoplasm Malignant

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2
Patients
730 (planned)
Started
Aug 18, 2021
Main results expected
Mar 22, 2027
Fully finished
Mar 22, 2027
Results posted
not yet

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Arm 1: Number of Participants Who Experience at Least One Dose-limiting Toxicity (DLT)

    Measured over: Up to approximately 21 days

  • Arm 1: Number of Participants Who Experience at Least One Adverse Event (AE)

    Measured over: Up to approximately 67 months

  • Arm 1: Number of Participants Who Discontinue Study Treatment Due to an AE

    Measured over: Up to approximately 67 months

  • Confirmed Objective Response Rate (ORR) Per Response Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Blinded Independent Central Review (BICR)

    Measured over: Up to approximately 67 months

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT04976634 · record last updated 2025-04-06 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT04976634) ↗