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Tremor shows what changed in public records. It never tells anyone to buy or sell. Many trial edits are harmless paperwork. Data from ClinicalTrials.gov, the SEC, and the Federal Register.

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MRKMerck Sharp & Dohme LLCSigning up patients

A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)

Chronic Lymphocytic Leukaemia · Small Lymphocytic Lymphoma · Hematologic Malignancies

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2
Patients
60 (planned)
Started
Oct 14, 2026
Main results expected
Nov 16, 2033
Fully finished
Nov 16, 2033
Results posted
not yet

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Cohort A Part 1: Number of Participants Who Experience Dose-Limiting Toxicity (DLT)

    Measured over: Up to approximately 29 days

  • Cohort A Part 1: Number of Participants Who Experience an AE

    Measured over: Up to approximately 27 months

  • Cohort A Part 1: Number of Participants Who Discontinue Study Treatment Due to an AE

    Measured over: Up to approximately 24 months

  • Cohort A Parts 1 and 2: Objective Response Rate (ORR)

    Measured over: Up to approximately 66 months

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT07709000 · record last updated 2026-11-04 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT07709000) ↗