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MRKMerck Sharp & Dohme LLCRunning, no new patients

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007)

Lymphoma, Large B-Cell, Diffuse (DLBCL)

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2
Patients
60 (planned)
Started
Jul 14, 2022
Main results expected
Apr 26, 2029
Fully finished
Apr 26, 2029
Results posted
not yet

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Number of Participants Who Experienced Dose-limiting Toxicities (DLTs) in Cycle 1

    Measured over: Cycle 1 (up to 21 days)

  • Number of Participants Who Experienced At Least One AE

    Measured over: Up to approximately 8 months

  • Number of Participants Who Discontinued Study Treatment Due to an AE

    Measured over: Up to approximately 5.5 months

  • Complete Response Rate (CRR) per Lugano Response Criteria

    Measured over: Up to approximately 60 months

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT05406401 · record last updated 2024-10-15 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT05406401) ↗