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MRKMerck Sharp & Dohme LLCFinished

Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)

Squamous Cell Carcinoma of Head and Neck

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2
Patients
408 (final count)
Started
Aug 6, 2020
Main results expected
May 31, 2024
Fully finished
Oct 30, 2025
Results posted
May 25, 2025

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Overall Survival (OS)

    Measured over: Up to approximately 45 months

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT04428151 · record last updated 2025-12-04 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT04428151) ↗