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Tremor shows what changed in public records. It never tells anyone to buy or sell. Many trial edits are harmless paperwork. Data from ClinicalTrials.gov, the SEC, and the Federal Register.

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MRKMerck Sharp & Dohme LLCFinished

A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

Advanced Non-Small Cell Lung Cancer

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2
Patients
245 (final count)
Started
Oct 1, 2018
Main results expected
Jun 13, 2025
Fully finished
Jun 13, 2025
Results posted
Jun 8, 2026

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Objective Response Rate (ORR)

    Measured over: Up to approximately 80 months

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT03516981 · record last updated 2026-06-08 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT03516981) ↗