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MRKMerck Sharp & Dohme LLCSigning up patients

A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)

B-cell Acute Lymphoblastic Leukemia

2Calmworry score, out of 100

No strong warning signs right now. The score counts warning signs; it is not a prediction.

Why this score

  • 5 insiders sold shares within a month

    Since Aug 13, 2026 · was worth 5, fading over time

    +1.9
Worry score2

Score over time

Stage
Phase 2/3
Patients
340 (planned)
Started
May 18, 2026
Main results expected
Oct 18, 2033
Fully finished
Oct 18, 2033
Results posted
not yet

What counts as success

The trial's main goal(s), called the “primary outcome.”

  • Percentage of Participants with Complete Remission (CR) in Study Part 1 and Part 2

    Measured over: 3 treatment cycles (up to approximately 126 days; each cycle is up to 42 days; cycle lengths vary between cycle and arm)

  • Percentage of Participants Who Experience an Adverse Event (AE) in Study Part 1

    Measured over: 3 treatment cycles (up to approximately 126 days; each cycle is up to 42 days; cycle lengths vary between cycle and arm)

  • Percentage of Participants Who Discontinue Study Intervention Due to an AE in Study Part 1

    Measured over: 3 treatment cycles (up to approximately 126 days; each cycle is up to 42 days; cycle lengths vary between cycle and arm)

  • Overall Survival (OS) in Study Part 2

    Measured over: Up to approximately 7 years

Changes Tremor has spotted

No changes since Tremor started watching this trial.
Show details (technical version)

Score inputs

  • insider_selling_cluster: base 5, now 1.9, since 2026-08-13, fades (half-life)

Raw record changes

  • none yet

Trial ID NCT07570173 · record last updated 2026-10-30 · checked 2026-11-09 15:47 UTC

See the official record on ClinicalTrials.gov (NCT07570173) ↗